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Identifiers
AGA Institute Rapid Review of the Gastrointestinal and Liver Manifestations of COVID-19, Meta-Analysis of International Data, and Recommendations for the Consultative Management of Patients with COVID-19
Gastroenterology
Background & Aims Multiple gastrointestinal (GI) symptoms, including diarrhea, nausea/vomiting, and abdominal pain, as well as liver enzyme abnormalities, have been variably reported in patients with coronavirus disease 2019 (COVID-19). This document provides best practice statements and recommendations for consultative management based on a systematic review and meta-analysis of international data on GI and liver manifestations of COVID-19. Methods We performed a systematic literature search to identify published and unpublished studies using OVID Medline and preprint servers (medRxiv, LitCovid, and SSRN) up until April 5, 2020; major journal sites were monitored for US publications until April 19, 2020. We pooled the prevalence of diarrhea, nausea, vomiting, and abdominal pain, as well as liver function tests abnormalities, using a fixed-effect model and assessed the certainty of evidence using the GRADE (Grading of Recommendations Assessment, Development and Evaluation) framework. Results We identif...
Topics in this document
Nausea
Liver function tests
Hepatitis
Lopinavir/ritonavir
Hepatotoxicity
Adverse effect
Chloroquine
Porphyria
Meta-analysis
Comorbidity
Hydroxychloroquine
Coronavirus
Inflammatory bowel disease
Hepatitis C
Remdesivir
Middle East respiratory syndrome
Severe acute respiratory syndrome coronavirus 2
Ritonavir
Diarrhea
Infection
Antimalarial medication
Abdominal pain
Epidemiology
Diseases and disorders
Health sciences
Health
Clinical medicine
Medicine
Medical specialties
Coronavirus disease 2019
Cites research funded by
3
National Natural Science Foundation of China
1
Natural Science Foundation of Anhui Province
1
National Science and Technology Major Project
1
Sanming Project of Medicine in Shenzhen
1
Shenzhen Science and Technology Research and Development Project
1
China Postdoctoral Science Foundation
1
Guangdong Special Fund for Science and Technology Innovation Strategy in 2020
1
Department of Science and Technology of Guangdong Province
1
Science and Technology Planning Project of Shenzen Municipality
1
Office of Electricity Delivery and Energy Reliability
2
Guangdong Science and Technology Department
1
Research and Development
1
MRC
1
NIHR (November 2024)
1
National Key Research and Development Programme of China
1
National Major Project for Control and Prevention of Infectious Disease in China
1
State Key Research Development Program of China
1
Strategic Priority Research Programme of the Chinese Academy of Sciences
1
Academic Promotion Programme of Shandong First Medical University
1
Taishan Scholars Programme of Shandong Province
1
Nanjing Agricultural University
4
NIH (Special project, May 2022)
1
U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases
1
Gilead Sciences
2
National Institute on Minority Health and Health Disparities
2
National Institute of Allergy and Infectious Diseases
1
FP7_REST_SecondPillar (Special project, May 2022)
1
FP7_REST_ALL (Special project, May 2022)
2
National High-tech Research and Development Program
2
OpenAlex NIH DOIs (April 2024)
2
National Institutes of Health
1
Health Resources and Services Administration
2
World Health Organization
1
HHS
1
CCR NIH HHS
1
NCI NIH HHS
1
Intramural NIH HHS
1
U.S. Department of Health and Human Services
1
Natural Science Foundation of Zhejiang Province
1
Natural Science Foundation of Ningbo
1
Shaoxing Municipal Science and Technology Plan Project
1
Basic Public Welfare Research Program of Zhejiang Province
1
Ningbo Municipal Bureau of Science and Technology
1
Natural Science Foundation of Guangdong Province
1
Guangdong Provincial Department of Science and Technology
1
National Health Commission
1
National Health Commission of the People's Republic of China
Citations
Cited by 3
other policy documents
(1 of them are from other policy sources)
Recognized names mentioned in this document
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Shazia M. Siddique
at University of Pennsylvania
Shahnaz Sultan
at University of Minnesota