Campbell Systematic Reviews (Wiley)
Jennifer Petkovic et al. 2017
These guidelines were updated in accordance with the WHO handbook for guideline development, 2012 (18). The process comprised multiple steps, including setting up a guideline development group, scoping the revision of the document, and setting up an external expert review group to guide the systematic reviews using the PICOT framework (which clearly defined the IPC intervention in terms of question, population, comparator and outcome), and the conduct of the systematic reviews, including evidence retrieval and synthesis. Where systematic reviews could not be undertaken, evidence-based reviews or critical appraisals of the literature were done instead. Evidence was synthesized and recommendations formulated using the GRADE framework (18, 46-50).