Policy document
July 29th 2016

Test No. 474: Mammalian Erythrocyte Micronucleus Test

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OECD
OECD
https://www.oecd.org Flag of igo IGO

The Organisation for Economic Co-operation and Development is an intergovernmental organization with 38 member countries, founded in 1961 to stimulate economic progress and world trade. It is a forum the members of which are countries describing themselves as committed to democracy and the market economy, providing a platform to compare policy experiences, seek answers to common problems, identify good practices and coordinate domestic and international policies of its members. The majority of OECD members are high-income economies with a very high Human Development Index (HDI) and are regarded as developed countries.
The mammalian in vivo micronucleus test is used for the detection of damage induced by the test substance to the chromosomes or the mitotic apparatus of erythroblasts, by analysis of erythrocytes as sampled in bone marrow and/or peripheral blood cells of animals, usually rodents (mice or rats).The purpose of the micronucleus test is to identify substances (liquid or solid) that cause cytogenetic damage which results in the formation of micronuclei containing lagging chromosome fragments or whole chromosomes. An increase in the frequency of micronucleated polychromatic erythrocytes in treated animals is an indication of induced chromosome damage. Animals are exposed to the test substance by an appropriate route (usually by gavage using a stomach tube or a suitable intubation cannula, or by intraperitoneal injection). Bone marrow and/or blood cells are collected, prepared and stained. Preparations are analyzed for the presence of micronuclei. Each treated and control group must include at least 5 analysable ...

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Identifiers

Overton ID
oecddiscovery-bfb14574fb9f0abc7e7131b7eed1fb69
doi
10.1787/9789264264762-en

Topics in this document

Micronucleus test Mitosis Genotoxicity Micronucleus Cell division Toxicity Experiment Dose (biochemistry) Analysis of variance Red blood cell Staining Scientific control Cell nucleus

Related COFOG Divisions

7: Health 7.5: R&D Health

Cites research funded by

U.S. Food and Drug Administration 2 National Institutes of Health 1 U.S. Department of Agriculture 1 National Institute of Environmental Health Sciences 2 Core Research for Evolutional Science and Technology 2 U.S. Department of Energy 1 Office of Science 1 Health Canada 1 Dow Chemical Company 1 American Chemistry Council 1

Citations

Cited by 80 other policy documents (74 of them are from other policy sources)