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Identifiers

Overton ID
oecddiscovery-6a8f4cef4d47ffbab651405fc693e6f7
doi
10.1787/9789264242340-en

Test No. 241: The Larval Amphibian Growth and Development Assay (LAGDA)

Flag for IGO OECD on July 28th 2015
The test guideline of the Larval Amphibian Growth and Development Assay (LAGDA) describes a toxicity test with an amphibian species (African clawed frog (Xenopus laevis)) that considers growth and development from fertilization through the early juvenile period. It is an assay (typically 16 weeks) that assesses early development, metamorphosis, survival, growth, and partial reproductive maturation. It also enables measurement of a suite of other endpoints that allows for diagnostic evaluation of suspected endocrine disrupting chemicals (EDCs) or other types of developmental and reproductive toxicants. The LAGDA serves as a higher tier test with an amphibian for collecting more comprehensive concentration-response information on adverse effects suitable for use in hazard identification and characterization, and in ecological risk assessment. The general experimental design entails exposing X. laevis embryos at Nieuwkoop and Faber (NF) stage 8-10 (3) to a minimum of four different concentrations of test chem...

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Cited by 21 other policy documents (19 of them are from other policy sources)