Policy document
April 19th 2006

Amantadine and rimantadine for influenza A in adults

Flag of USA USA
Guidelines in PubMed Central
Guidelines in PubMed Central
https://www.ncbi.nlm.nih.gov Flag of usa USA

This source collects the practice and clinical guidelines published in journals worldwide that are available on PubMed Central, an open repository of biomedical research run by the National Institutes of Health in the USA.
The Cochrane Database of Systematic Reviews
Abstract Background Amantadine hydrochloride (amantadine) and rimantadine hydrochloride (rimantadine) have antiviral properties, but they are not widely used due to a lack of knowledge of their potential value and concerns about possible adverse effects. This review was first published in 1999 and updated for the fourth time in April 2008. Objectives The objective of this review was to assess the efficacy, effectiveness and safety ('effects') of amantadine and rimantadine in healthy adults. Search methods We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2008, issue 1), MEDLINE (1966 to April Week 4, 2008), EMBASE (1990 to April 2008) and reference lists of articles. Selection criteria Randomised and quasi‐randomised studies comparing amantadine and/or rimantadine with placebo, control medication or no intervention, or comparing doses or schedules of amantadine and/or rimantadine in healthy adults. Data collection and analysis For prophylaxis (prevention) tria...

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Language: eng
60 pages

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Identifiers

Overton ID
pubmedcentral-0bf41c5eda8ff22fb0715c759b5cd8e7
doi
10.1002/14651858.cd001169.pub3

Topics in this document

Medicine Randomized controlled trial Influenza Amantadine Systematic review Vaccine efficacy Cochrane (organisation) Blinded experiment Placebo Rimantadine Confidence interval Influenza A virus subtype H1N1 Influenza A virus subtype H3N2 Placebo-controlled study Adverse effect Meta-analysis Antiviral drug Influenza vaccine Health sciences Medical specialties Health Clinical medicine Health care Preventive healthcare Clinical trial Diseases and disorders Public health Infection Allocation concealment Risk

Related SDGs

SDG 3: Good Health and Well-being
SDG 3: Good Health and Well-being

Target 3.3

End the epidemics of AIDS, tuberculosis, malaria and neglected tropical diseases and combat hepatitis, water-borne diseases and other communicable diseases

Related COFOG Divisions

7: Health 7.1: Medical Products, Appliances and Equipment

Cites research funded by

DuPont 2 Centers for Disease Control and Prevention 1 GlaxoSmithKline 1 Sanofi 1 Ministère de la Défense Nationale 1 National Institute of Allergy and Infectious Diseases 4 National Institutes of Health 3 University of Rochester 1

Citations

Cited by 18 other policy documents (12 of them are from other policy sources)