Policy document
July 28th 2015

Test No. 421: Reproduction/Developmental Toxicity Screening Test

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OECD
OECD
https://www.oecd.org Flag of igo IGO

The Organisation for Economic Co-operation and Development is an intergovernmental organization with 38 member countries, founded in 1961 to stimulate economic progress and world trade. It is a forum the members of which are countries describing themselves as committed to democracy and the market economy, providing a platform to compare policy experiences, seek answers to common problems, identify good practices and coordinate domestic and international policies of its members. The majority of OECD members are high-income economies with a very high Human Development Index (HDI) and are regarded as developed countries.
This screening Test Guideline describes the effects of a test chemical on male and female reproductive performance. It has been updated with endocrine disruptor endpoints, in particular measure of anogenital distance and male nipple retention in pups and thyroid examination.The test substance is administered in graduated doses to several groups of males and females. Males should be dosed for a minimum of four weeks. Females should be dosed throughout the study, so approximately 63 days. Matings "one male to one female" should normally be used in this study. This Test Guideline is designed for use with the rat. It is recommended that each group be started with at least 10 animals of each sex. Generally, at least three test groups and a control group should be used. Dose levels may be based on information from acute toxicity tests or on results from repeated dose studies. The test substance is administered orally and daily. The results of this study include clinical observations, body weight and food/water c...

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Identifiers

Overton ID
oecddiscovery-121992e2c84649f77d1d2dac1649ec91
doi
10.1787/9789264242692-en

Topics in this document

Dose (biochemistry) Toxicity Pregnancy Endocrine disruptor Childbirth Toxicology Estrous cycle Fixation (histology) Thyroid Thyroid hormones Pap test Histopathology Water Medical specialties Hormone OECD Vagina Health sciences Testicle Animal testing Clinical medicine Health Developmental toxicity Reproductive toxicity Pathology Statistics Prostate Cervix Mating Medicine

Related SDGs

SDG 3: Good Health and Well-being
SDG 3: Good Health and Well-being

Target 3.7

Ensure universal access to sexual and reproductive health-care services, including for family planning, information and education, and the integration of reproductive health into national strategies and programmes

SDG 12: Responsible Consumption and Production
SDG 12: Responsible Consumption and Production

Target 12.4

Achieve the environmentally sound management of chemicals and all wastes throughout their life cycle, in accordance with agreed international frameworks, and significantly reduce their release to air, water and soil in order to minimize their adverse impacts on human health and the environment

Related COFOG Divisions

7: Health 7.5: R&D Health

Citations

Cited by 3 other policy documents (all of them are from other policy sources)