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Identifiers

Overton ID
oecddiscovery-121992e2c84649f77d1d2dac1649ec91
doi
10.1787/9789264242692-en

Test No. 421: Reproduction/Developmental Toxicity Screening Test

Flag for IGO OECD on July 28th 2015
This screening Test Guideline describes the effects of a test chemical on male and female reproductive performance. It has been updated with endocrine disruptor endpoints, in particular measure of anogenital distance and male nipple retention in pups and thyroid examination.The test substance is administered in graduated doses to several groups of males and females. Males should be dosed for a minimum of four weeks. Females should be dosed throughout the study, so approximately 63 days. Matings "one male to one female" should normally be used in this study. This Test Guideline is designed for use with the rat. It is recommended that each group be started with at least 10 animals of each sex. Generally, at least three test groups and a control group should be used. Dose levels may be based on information from acute toxicity tests or on results from repeated dose studies. The test substance is administered orally and daily. The results of this study include clinical observations, body weight and food/water c...

Topics in this document

Related SDGs

SDG 3: Good Health and Well-being ...
SDG 3: Good Health and Well-being

Target 3.7

Ensure universal access to sexual and reproductive health-care services, including for family planning, information and education, and the integration of reproductive health into national strategies and programmes
SDG 12: Responsible Consumption and Production ...
SDG 12: Responsible Consumption and Production

Target 12.4

Achieve the environmentally sound management of chemicals and all wastes throughout their life cycle, in accordance with agreed international frameworks, and significantly reduce their release to air, water and soil in order to minimize their adverse impacts on human health and the environment

Citations

Cited by 3 other policy documents (all of them are from other policy sources)