Policy document
June 14th 1996

Test No. 305: Bioconcentration: Flow-through Fish Test

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OECD
OECD
https://www.oecd.org Flag of igo IGO

The Organisation for Economic Co-operation and Development is an intergovernmental organization with 38 member countries, founded in 1961 to stimulate economic progress and world trade. It is a forum the members of which are countries describing themselves as committed to democracy and the market economy, providing a platform to compare policy experiences, seek answers to common problems, identify good practices and coordinate domestic and international policies of its members. The majority of OECD members are high-income economies with a very high Human Development Index (HDI) and are regarded as developed countries.
This Test Guideline describes a procedure for characterising the bioconcentration potential of substances in fish, under flow-through conditions (but semi-static regimes are permissible). The test consists of two phases: the exposure (uptake) and post-exposure (depuration) phases. During the uptake phase (28 days normally and 60 days maximum), separate groups of four fishes of one species are exposed to at least two concentrations of the test substance. They are then transferred to a medium free of the test substance for the depuration phase. A depuration phase is always necessary unless uptake of the substance during the uptake phase has been insignificant. In addition to the two test concentrations, a control group of fish is held without the test substance. The concentration of the test substance in/on the fish is followed through both phases of the test. During the test, dissolved oxygen, TOC, pH, total hardness and salinity, and temperature should be measured in vessels. The lipid content should be de...

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Identifiers

Overton ID
oecddiscovery-296808db3d26e729180b4f2ad50d5845
doi
10.1787/9789264070462-en

Topics in this document

Pharmacokinetics Total organic carbon Water Partition coefficient Physical sciences Chemistry Bioconcentration Isotopic labeling Solubility Rate equation Reaction rate constant Materials Salinity Bioaccumulation Chemical substance

Related SDGs

SDG 6: Clean Water and Sanitation
SDG 6: Clean Water and Sanitation

Target 6.3

Improve water quality by reducing pollution, eliminating dumping and minimizing release of hazardous chemicals and materials, halving the proportion of untreated wastewater and substantially increasing recycling and safe reuse globally

SDG 12: Responsible Consumption and Production
SDG 12: Responsible Consumption and Production

Target 12.4

Achieve the environmentally sound management of chemicals and all wastes throughout their life cycle, in accordance with agreed international frameworks, and significantly reduce their release to air, water and soil in order to minimize their adverse impacts on human health and the environment

Related COFOG Divisions

5: Environmental Protection 5.3: Pollution Abatement

Citations

Cited by 42 other policy documents (39 of them are from other policy sources)