Policy document
April 4th 1984

Test No. 478: Genetic Toxicology: Rodent Dominant Lethal Test

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OECD
OECD
https://www.oecd.org Flag of igo IGO

The Organisation for Economic Co-operation and Development is an intergovernmental organization with 38 member countries, founded in 1961 to stimulate economic progress and world trade. It is a forum the members of which are countries describing themselves as committed to democracy and the market economy, providing a platform to compare policy experiences, seek answers to common problems, identify good practices and coordinate domestic and international policies of its members. The majority of OECD members are high-income economies with a very high Human Development Index (HDI) and are regarded as developed countries.
Dominant lethal (DL) effects cause embryonic or foetal death. Induction of a dominant lethal event after exposure to a test substance (liquid, solid, vapour or gas, …) indicates that the substance has affected germinal tissue of the test species. Dominant lethals are generally accepted to be the result of chromosomal aberrations (structural and numerical anomalies), but gene mutations and toxic effects cannot be excluded. This Test Guideline recommends rats or mice as the test species. Generally, male animals are exposed to the test substance and mated to untreated virgin females. The most widely used is the single administration of the test substance by oral or by intraperitoneal injection. Normally, three dose levels should be used. The various germ cell stages can be tested separately by the use of sequential mating intervals. The females are sacrificed after an appropriate period of time, and the contents of the uteri are examined to determine the numbers of implants and live and dead embryos. The ca...

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Identifiers

Overton ID
oecddiscovery-29c054adce12f8aa5497ed2cd7b8deb3
doi
10.1787/9789264071360-en

Topics in this document

Reproduction Toxicity Dose (biochemistry) Toxicology Medical specialties Biology Clinical medicine Pregnancy Health sciences Health

Related COFOG Divisions

7: Health 7.5: R&D Health

Citations

Cited by 6 other policy documents (5 of them are from other policy sources)