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Identifiers

Overton ID
oecddiscovery-2a62ff62548483af970271505e14c172
doi
10.1787/9789264070820-en

Test No. 414: Prenatal Developmental Toxicity Study

Flag for IGO OECD on June 27th 2018
This Test Guideline for developmental toxicity testing is designed to provide general information concerning the effects of prenatal exposure on the pregnant test animal and on the developing organism. The test substance is normally administered to pregnant animals at least from implantation to one day prior to the day of scheduled kill, which should be as close as possible to the normal day of delivery. This Test Guideline is intended for use with rodent (rat preferably) and non-rodent (rabbit preferably). Each test and control group should contain a sufficient number of females to result in approximately 20 female animals with implantation sites at necropsy. Three concentrations, at least, should be used. The test substance or vehicle is usually administered orally by intubation. A limit test may be performed if no effects would be expected at a dose of 1000 mg/kg bw/d. The results of this study include measurements (weighing) and clinical daily observations, each day preferably at the same time. Shortly...

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Related SDGs

SDG 3: Good Health and Well-being ...
SDG 3: Good Health and Well-being

Target 3.1

Reduce the global maternal mortality ratio to less than 70 per 100,000 live births

Citations

Cited by 51 other policy documents (50 of them are from other policy sources)