Policy document
July 11th 2006

Test No. 123: Partition Coefficient (1-Octanol/Water): Slow-Stirring Method

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OECD
OECD
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The Organisation for Economic Co-operation and Development is an intergovernmental organization with 38 member countries, founded in 1961 to stimulate economic progress and world trade. It is a forum the members of which are countries describing themselves as committed to democracy and the market economy, providing a platform to compare policy experiences, seek answers to common problems, identify good practices and coordinate domestic and international policies of its members. The majority of OECD members are high-income economies with a very high Human Development Index (HDI) and are regarded as developed countries.
This Test Guideline describes the slow-stirring method, which permits the determination of the 1-octanol/water partition coefficient (POW) values up to a log POW of 8.2. The partition coefficient between water and 1-octanol (POW) is defined as the ratio of the equilibrium concentrations of the pure test substance in 1-octanol saturated with water (CO) and water saturated with 1-octanol (CW). In order to determine the partitioning coefficient, water, 1-octanol, and the test substance are equilibrated with each other at constant temperature in a thermostated stirred reactor at 25 °C and protected from daylight. Exchange between the phases is accelerated by stirring. The concentrations of the test substance in the two phases are determined. Each POW determination has to be performed employing at least three independent slow-stirring experiments with identical conditions. The regression used to demonstrate attainment of equilibrium should be based on the results of at least four determinations of CO / CW at c...

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Identifiers

Overton ID
oecddiscovery-3fa2db876b98f30f53af737ca891efc2
doi
10.1787/9789264015845-en

Topics in this document

Solubility Detection limit Physical sciences Chemistry Physical chemistry Applied and interdisciplinary physics Analytical chemistry Analysis Partition coefficient Weighted arithmetic mean Equilibrium chemistry Chemical substance Water Chemical substances Materials Experiment Liquid–liquid extraction Chemical equilibrium Standard deviation Variance

Related SDGs

SDG 12: Responsible Consumption and Production
SDG 12: Responsible Consumption and Production

Target 12.4

Achieve the environmentally sound management of chemicals and all wastes throughout their life cycle, in accordance with agreed international frameworks, and significantly reduce their release to air, water and soil in order to minimize their adverse impacts on human health and the environment

Related COFOG Divisions

5: Environmental Protection 5.3: Pollution Abatement

Citations

Cited by 27 other policy documents (17 of them are from other policy sources)