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Identifiers

Overton ID
oecddiscovery-89349d5611efe4bbb97420d73d61caf8
doi
10.1787/9789264070608-en

Test No. 403: Acute Inhalation Toxicity

Flag for IGO OECD on September 8th 2009
This method provides information on health hazard likely to arise from short-term exposure to a test article (gas, vapour or aerosol/particulate test article) by inhalation. The revised Test Guideline describes two studies: a traditional LC50 protocol and a Concentration x Time (C x t) protocol. It can be used to estimate a median lethal concentration (LC50), non-lethal threshold concentration (LC01) and slope, and to identify possible sex susceptibility. This Test Guideline enables a test article quantitative risk assessment and classification according to the Globally Harmonized System for the Classification and Labelling of Chemicals. In the traditional LC50 protocol, animals are exposed to one limit concentration or to three concentrations, at least, for a predetermined duration, generally of 4 hours. Usually 10 animals should be used for each concentration. In the C x T protocol, animals are exposed to one limit concentration or a series of concentrations over multiple time durations. Usually 2 animal...

Topics in this document

Related SDGs

SDG 12: Responsible Consumption and Production ...
SDG 12: Responsible Consumption and Production

Target 12.4

Achieve the environmentally sound management of chemicals and all wastes throughout their life cycle, in accordance with agreed international frameworks, and significantly reduce their release to air, water and soil in order to minimize their adverse impacts on human health and the environment

Citations

Cited by 39 other policy documents (38 of them are from other policy sources)