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Identifiers

Overton ID
oecddiscovery-bace994bd6d6cdd00015cba469c72187
doi
10.1787/9789264070882-en

Test No. 417: Toxicokinetics

Flag for IGO OECD on July 23rd 2010
This Test Guideline describes in vivo studies that provide information on mass balance, absorption, bioavailability, tissue distribution, metabolism, excretion, and basic toxicokinetic parameters [e.g. AUC], as well as supplemental approaches that may provide useful information on toxicokinetics. Information from toxicokinetic studies helps to relate concentration or dose to the observed toxicity and to understand its mechanism of toxicity. The test substance ("unlabelled" or "radiolabelled" forms) is normally administered by an oral route, but other routes of administration may be applicable. Single dose administration of the substance (preferably a minimum of two dose levels) may be adequate, but repeated dose may be needed in some circumstances. Toxicokinetic studies should preferably be carried out in the same species as that used in other toxicological studies performed with the substance (normally the rat, a minimum of 4 animals of one sex for each dose). Initial estimation of absorption can be achie...

Topics in this document

Related SDGs

SDG 12: Responsible Consumption and Production ...
SDG 12: Responsible Consumption and Production

Target 12.4

Achieve the environmentally sound management of chemicals and all wastes throughout their life cycle, in accordance with agreed international frameworks, and significantly reduce their release to air, water and soil in order to minimize their adverse impacts on human health and the environment

Citations

Cited by 33 other policy documents (32 of them are from other policy sources)