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Identifiers

doi
10.1002/14651858.cd001169.pub3

Amantadine and rimantadine for influenza A in adults

Flag for USA Guidelines in PubMed Central on April 19th 2006
The Cochrane Database of Systematic Reviews
Abstract Background Amantadine hydrochloride (amantadine) and rimantadine hydrochloride (rimantadine) have antiviral properties, but they are not widely used due to a lack of knowledge of their potential value and concerns about possible adverse effects. This review was first published in 1999 and updated for the fourth time in April 2008. Objectives The objective of this review was to assess the efficacy, effectiveness and safety ('effects') of amantadine and rimantadine in healthy adults. Search methods We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2008, issue 1), MEDLINE (1966 to April Week 4, 2008), EMBASE (1990 to April 2008) and reference lists of articles. Selection criteria Randomised and quasi‐randomised studies comparing amantadine and/or rimantadine with placebo, control medication or no intervention, or comparing doses or schedules of amantadine and/or rimantadine in healthy adults. Data collection and analysis For prophylaxis (prevention) tria...

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Cited by 11 other policy documents (7 of them are from other policy sources)